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IGF-I immunoreactivity has been detected in satellite cell and in cytoplasm of myoblasts and myotubes during skeletal muscle regeneration 8183 , while IGF-I mRNA and protein expression have been detected in newly replicating skeletal muscle following injury in rats 84

Scientific evidences has demonstrated a substantial association between diabetes (both T1D and T2D) and cognitive decline leading to dementia in animal models and humans [29, 49, 114, 115]

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