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Only some features of the GH-IGF-1 axis appear to be dependent on the different genotypes

For most patients on stable doses, a single day shift is unlikely to cause serious harm, but it does carry real risks including nausea, vomiting, fatigue, or stomach discomfort

Seek emergency medical care immediately if you experience: Severe abdominal pain: Particularly sudden-onset, persistent pain in the upper abdomen that may radiate to your back Persistent nausea and vomiting: Especially if unable to keep down food or liquids for more than 24 hours Fever with abdominal pain: Temperature above 100.4F (38C) accompanied by abdominal symptoms Abdominal distension or rigidity: Swelling or hardness of the abdomen with severe tenderness If you develop severe, persistent upper abdominal pain (with or without vomiting), stop tirzepatide and seek urgent medical evaluation