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Ultrafast excited-state dynamics and photolysis studies have revealed that a new channel for rapid nonradiative decay in base-o MeCbl is opened, which competes with bond dissociation

Co-administration with simvastatin (a CYP3A substrate) resulted in 8% decrease in extent of absorption (AUCinf) and 5% increase in rate of absorption (Cmax) of simvastatin

Lifestyle, dietary, and environmental recommendations arent just for people with MTHFR C677T or A1298C variants (or however you prefer to label them)

Women taking long-term medications such as metformin (for diabetes or polycystic ovary syndrome) or proton pump inhibitors (for acid reflux) may also have reduced B12 absorption