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One such substance, LY3437943, has been discovered to exhibit strong agonist activity on three distinct receptors, including the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors

Any potential immunomodulatory effects require rigorous investigation through properly designed clinical trials before therapeutic recommendations can be made

For guidance on switching between GLP-1 medications , similar transition principles apply

Therefore, if GLP-1 RA treatment specifically increases the risk of pancreatitis in this vulnerable population, such an effect would likely remain undetected in randomized trials