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10.1016/j.tox.2019.02.011 Toxicology 78 HouW.XieY.SongX.SunX.LotzeM

Indeed, elevated plasma TMAO levels may increase the risk of atherosclerotic cardiovascular disease (ASCVD) (Yang et al., 2019

In September 2025, Hanmi filed an investigational new drug application for a Phase III clinical trial evaluating combination therapy with SGLT-2 inhibitors and metformin, which was approved on Jan

The risk of pancreatitis with GLP-1 agonist medications is well-documented, though the incidence remains very low (0.27% to 2.2%, depending on the study)