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Potential Risks or Downsides of NAD+ Anti-Aging Injections Even though NAD+ is natural, injections still carry potential risks, including: Nausea, flushing, chest or abdominal discomfort during IV infusion Headaches or fatigue afterward Pain, bruising, or infection at injection sites Phlebitis (vein inflammation) Allergic reactions to components of the infusion Unknown long-term safety, especially with repeated high doses There are also theoretical concerns for individuals with a history of cancer because NAD+ pathways play a role in cell growth and repair