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TGF-1 levels are significantly elevated in the synovial fluid and tissues of RA patients, where it contributes to disease progression by promoting fibroblast proliferation, synovial hypertrophy, and extracellular matrix degradation (Bira et al

Clin Exp Rheumatol (2020) 38(6):114554

In response, Juniper stated: A deviation from protocols was identified which does not reflect our usual practice and we will be taking the appropriate action

The in vivo effects of AT-7687 were evaluated in obese cynomolgus monkeys, and when combined with the GLP-1 analogue liraglutide, AT-7687 enhances weight reduction induced by liraglutide and improves glycemic control and lipid metabolism (51)