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GSH is also critical in the detoxification of xenobiotics (drugs, pollutants, carcinogens) through a broad range of reactions with GSH- dependent enzymes containing a redox sensitive cysteine ( Cys ) residue that undergoes reversible oxidation and reduction at the active site: GSH reductase ( GR ), glutaredoxin ( Grx ), and the families of GSH peroxidases ( Gpxs ) and GSH-S-transferases ( GSTs )

It is not permitted to perform homocysteine testing to confirm vitamin B12 deficit

Thus, elevations in GGT on the external cellular membrane are correlated directly to relative GSH deficiency in the cellular cytoplasm of the host cell