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Shaking introduces strong shearing forces that can physically break the fragile peptide bonds

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This effect involves upregulation of integrin receptors, particularly alpha5beta1 and alpha2beta1, which mediate keratinocyte attachment to provisional matrix proteins including fibronectin and collagen

Maffetone [email protected] These authors have contributed equally to this work This article was submitted to Public Health and Nutrition, a section of the journal Frontiers in Public Health Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers