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Meanwhile, another part of MLKL oligomers translocates into the membranes of various organelles e.g., nucleus, mitochondria, endoplasmic reticulum (ER), and lysosomes, causing their damage via necroptotic cell death (Li L

Patients with T2DM are usually older than 65 years old, with varying degrees of potential insulin resistance and uncontrolled hyperglycemia (Perreault et al., 2021)

Aged female mice received a high-fat diet combined with angiotensin II administration, producing a phenotype that recapitulated human cardiometabolic HFpEF: obesity, glucose intolerance, inflammation, cardiac hypertrophy, fibrosis, atrial enlargement, and lung congestion

Established alcohol treatment still sets the clinical standard